Drug Interactions:Ĭoncomitant topical medication, medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices or lime should be used with caution because of possible interaction with Tretinoin.
#Curology tretinoin percentages skin#
Tretinoin has been reported to cause severe irritation on eczematous skin and should be used with utmost caution in patients with this condition. If the degree of local irritation warrants, patients should be directed to use the medication less frequently, discontinue use temporarily, or discontinue use altogether. Topical use may induce severe local erythema and peeling at the site of application. Tretinoin preparations for acne treatment should be kept away from the eyes, the mouth, angles of the nose, and mucous membranes. Weather extremes, such as wind or cold, also may be irritating to patients under treatment with Tretinoin. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided. Patients who may be required to have considerable sun exposure due to occupation and those with inherent sensitivity to the sun should exercise particular caution. Exposure to sunlight, including sunlamps, should be minimized during the use of Tretinoin, and patients with sunburn should be advised not to use the product until fully recovered because of heightened susceptibility to sunlight as a result of the use of Tretinoin.
If a reaction suggesting sensitivity or chemical irritation occurs, use of the medication should be discontinued.
Do not expose to heat or store at temperatures above 120☏ (49☌). Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted. The safety and efficacy of the long-term use of this product in the treatment of other disorders have not been established. Tretinoin gel and cream are indicated for topical application in the treatment of acne vulgaris. Additionally, Tretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells causing extrusion of the comedones. Although the exact mode of action of Tretinoin is unknown, current evidence suggests that topical Tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedo formation.
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